Search for safer pain relief advances with new compounds

Journal Reference: Edward L. Stahl, Cullen L. Schmid, Agnes Acevedo-Canabal, Cai Read, Travis W. Grim, Nicole M. Kennedy, Thomas D. Bannister, Laura M. Bohn. G protein signaling–biased mu opioid receptor agonists that produce sustained G protein activation are noncompetitive agonists. Proceedings of the National Academy of Sciences, 2021; 118 (48): e2102178118 DOI: 10.1073/pnas.2102178118 Writing Nov. … Read more

In Doha, the Taliban in search of dialogue with the West

Taliban Foreign Minister Amir Khan Muttaqi (second from left) on August 12, 2021, in Doha, Qatar. KARIM JAAFAR / AFP The future of Afghanistan continues to be written, in part, in Doha, Qatar. A delegation from the Taliban government began on Saturday, November 27, a series of meetings with representatives of Western countries to try … Read more

Algeria in search of a response to the Morocco-Israel military axis

To not miss anything on African news, subscribe to the newsletter of World Africa from this link. Every Saturday at 6 a.m., find a week of current events and debates treated by the editorial staff of World Africa. Algerian Foreign Minister Ramtane Lamamra at a press conference in Algiers, August 24, 2021. RYAD KRAMDI / … Read more

Soccer: ManUnited on a delicate search for a coach

Football On Sunday, Manchester United parted ways with coach Ole Gunnar Solskjaer after losing 4-1 to Watford. Since the previous assistant Michael Carrick is only intended as an interim solution, the “Red Devils” have already started looking for a coach. However, this is not very easy. Desired solution Zinedine Zidane is said to have no … Read more

Life on Mars search could be misled by false fossils, study says

Journal Reference: Sean McMahon, Julie Cosmidis. False biosignatures on Mars: anticipating ambiguity. Journal of the Geological Society, 2021; jgs2021-050 DOI: 10.1144/jgs2021-050 Rocks on Mars may contain numerous types of non-biological deposits that look similar to the kinds of fossils likely to be found if the planet ever supported life, a study says. Telling these false … Read more

Novel gene therapy platform speeds search for ways to cure blindness

Journal Reference: Bilge E Öztürk, Molly E Johnson, Michael Kleyman, Serhan Turunç, Jing He, Sara Jabalameli, Zhouhuan Xi, Meike Visel, Valérie L Dufour, Simone Iwabe, Felipe Pompeo Marinho, Gustavo D Aguirre, José-Alain Sahel, David V Schaffer, Andreas R Pfenning, John G Flannery, William A Beltran, William R Stauffer, Leah C Byrne. scAAVengr, a transcriptome-based pipeline … Read more