Repurposed ALS drug shows promise in mouse model of rare childhood genetic disorder

Journal Reference: Antony Cougnoux, Julia C. Yerger, Mason Fellmeth, Jenny Serra-Vinardell, Fatemeh Navid, Christopher A. Wassif, Niamh X. Cawley, Forbes D. Porter. Reduction of glutamate neurotoxicity: A novel therapeutic approach for Niemann-Pick disease, type C1. Molecular Genetics and Metabolism, 2021; DOI: 10.1016/j.ymgme.2021.11.008 The study was conducted by Forbes D. Porter, M.D., Ph.D., of NIH’s Eunice … Read more

A stunning 3D map of blood vessels and cells in a mouse skull could help scientists make new bones

A stunning 3D map of blood vessels and cells in a mouse skull could help scientists make new bones – NovLink Home Mash O A stunning 3D map of blood vessels and cells in a mouse skull could help scientists make new bones We want to thank the author of this article for this incredible … Read more

New optical technology spotlights how memories move in mouse brains during sleep

Journal Reference: Akihiro Goto, Ayaka Bota, Ken Miya, Jingbo Wang, Suzune Tsukamoto, Xinzhi Jiang, Daichi Hirai, Masanori Murayama, Tomoki Matsuda, Thomas J. McHugh, Takeharu Nagai, Yasunori Hayashi. Stepwise synaptic plasticity events drive the early phase of memory consolidation. Science, 2021; 374 (6569): 857 DOI: 10.1126/science.abj9195 Publishing in the journal Science, Kyoto University’s Akihiro Goto uses … Read more

Zika virus-specific therapy protects the fetal mouse brain

Journal Reference: Rui Zhang, Yuxuan Fu, Min Cheng, Wenyuan Ma, Nan Zheng, Yongxiang Wang, Zhiwei Wu. sEVsRVG selectively delivers antiviral siRNA to fetus brain, inhibits ZIKV infection and mitigates ZIKV-induced microcephaly in mouse model. Molecular Therapy, 2021; DOI: 10.1016/j.ymthe.2021.10.009 “Our experiments indicated that targeted delivery via modified sEVs is a promising alternative to the traditional methods … Read more

Restoring normal sleep reduces amyloid-beta accumulation in mouse model of Alzheimer’s disease

Restoring normal sleep reduces amyloid-beta accumulation in mouse model of Alzheimer’s disease – NovLink Home Mash I Restoring normal sleep reduces amyloid-beta accumulation in mouse model of Alzheimer’s disease We would love to give thanks to the writer of this short article for this remarkable material Restoring normal sleep reduces amyloid-beta accumulation in mouse model … Read more

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