ALS therapy should target mind, not just spine

Journal Reference: Barış Genç, Javier H. Jara, Santana S. Sanchez, Amiko K. B. Lagrimas, Öge Gözütok, Nuran Koçak, Yongling Zhu, P. Hande Özdinler. Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient to improve cellular integrity of diseased upper motor neurons. Gene Therapy, 2021; DOI: 10.1038/s41434-021-00303-4 A new Northwestern … Read more

Repurposed ALS drug shows promise in mouse model of rare childhood genetic disorder

Journal Reference: Antony Cougnoux, Julia C. Yerger, Mason Fellmeth, Jenny Serra-Vinardell, Fatemeh Navid, Christopher A. Wassif, Niamh X. Cawley, Forbes D. Porter. Reduction of glutamate neurotoxicity: A novel therapeutic approach for Niemann-Pick disease, type C1. Molecular Genetics and Metabolism, 2021; DOI: 10.1016/j.ymgme.2021.11.008 The study was conducted by Forbes D. Porter, M.D., Ph.D., of NIH’s Eunice … Read more

Researchers discover new insights about tau proteins in people living with ALS

Journal Reference: Tiziana Petrozziello, Ana C. Amaral, Simon Dujardin, Sali M. K. Farhan, James Chan, Bianca A. Trombetta, Pia Kivisäkk, Alexandra N. Mills, Evan A. Bordt, Spencer E. Kim, Patrick M. Dooley, Caitlin Commins, Theresa R. Connors, Derek H. Oakley, Anubrata Ghosal, Teresa Gomez‐Isla, Bradley T. Hyman, Steven E. Arnold, Tara Spires‐Jones, Merit E. Cudkowicz, … Read more

Research uncovers new insights on ALS and points to a potentially promising treatment strategy

Research uncovers new insights on ALS and points to a potentially promising treatment strategy – NovLink Home Mash I Research uncovers new insights on ALS and points to a potentially promising treatment strategy We would like to give thanks to the author of this write-up for this remarkable content Research uncovers new insights on ALS … Read more

Hansi Flick ist jetzt schon besser als Joachim Löw

Liechtenstein ist keine Herausforderung für die deutsche Fußball-Nationalmannschaft, die entsprechend deutlich siegt. Ein früher Platzverweis hilft dabei ebenso wie lange vermisste Begeisterung auf den Rängen. Die Löw-Verabschiedung wirkt aber etwas wenig glamourös. Was ist in der Arena in Wolfsburg passiert? Dafür, dass es ein sportlich kaum relevantes Länderspiel ist, war der Vorlauf zum vorletzten Auftritt … Read more

Discovery of the role of a key gene in the development of ALS

Journal Reference: Zoé Butti, Yingzhou Edward Pan, Jean Giacomotto, Shunmoogum A. Patten. Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish. Communications Biology, 2021; 4 (1) DOI: 10.1038/s42003-021-02302-y A mutation in the C9orf72 gene is the primary genetic cause of ALS. The mutation in C9orf72 consists of an expansion of … Read more

ALS and dementia attacked by an RNA-hunting compound that recruits cell’s own virus fighter

ALS and dementia attacked by an RNA-hunting compound that recruits cell’s own virus fighter – NovLink Home Mash E ALS and dementia attacked by an RNA-hunting compound that recruits cell’s own virus fighter We would like to thank the writer of this write-up for this amazing content ALS and dementia attacked by an RNA-hunting compound … Read more

Bofads